Structural Determinants of Fast Desensitization and Desensitization–Deactivation Coupling in GABAAReceptors
نویسندگان
چکیده
منابع مشابه
Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAa receptors.
Fast IPSCs in the brain are predominantly caused by presynaptic release of GABA that activates GABA(A) receptor (GABA(A)R) channels. The IPSCs are shaped by the gating and desensitization properties of postsynaptic GABA(A)Rs. Specifically, fast desensitization has been suggested to decrease IPSC amplitude and to increase IPSC duration by slowing deactivation; however, the mechanisms underlying ...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2001
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.21-04-01127.2001